Paper sensors to monitor blood sugar for diabetic

Paper sensors to monitor blood sugar for...

 

Scientists have developed disposable paper-based sensors that can measure glucose concentrations in saliva, paving the way for a pain-free alternative to diabetic for monitoring their blood sugar levels daily. Strips of pH-sensitive paper are commonly used to test whether a liquid is acidic or alkaline. Researchers are now working to apply similar principles to create paper sensors that quickly indicate disease biomarkers.

Key to this approach is replacing traditional electronic circuitry in the sensors with low-cost plastics that can be manufactured quickly and in large quantities.

A team from the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia used inkjet technology to produce sensors sensitive to small sugar concentrations in biofluids.

Utilising a commercial ink made from conducting polymers, the team printed microscale electrode patterns onto glossy paper sheets. They printed a sensing layer containing an enzyme, glucose oxidase, on top of the tiny electrodes.

The biochemical reaction between available glucose and the enzyme creates electrical signals easily correlated to blood sugar levels.

“Paper is porous, which makes it challenging to print conducting and biological inks that are dissolved in water,” said Eloise Bihar, a postdoctoral researcher at KAUST.

“Printing the enzyme is tricky, as well -- it’s sensitive to variations of temperature, the voltage applied at the cartridge, and the pH of the ink,” said Bihar.

While fluids, such as sweat or saliva, contain enough sugar for monitoring purposes, they also contain molecules, such as ascorbic acid, that interfere electrically with conducting polymers.

Coating the sensor with a nafion polymer membrane that repels the negative charges present in most interfering species enabled measurement of only the relevant glucose levels in saliva samples from volunteers.

Experiments showed the top coating gave the sensor an unprecedented shelf life -- the enzyme could be kept alive and active for a month if stored in a sealed bag.

These results are encouraging the team to expand the capabilities of this approach by incorporating different enzymes into the sensing layer.


PostedOn: 28 Dec 2018 Total Views: 188




Organic and environmental friendly choco...

Organic and environmental friendly chocolates

Dana Mroueh’s chocolate factory is a rarity for Ivory Coast and not only because the world’s top has cocoa grower produced precious little finished chocolate. In the middle of the floor of her company Mon Choco’s factory sits a grinding bike, surrounded by trays of carefully sorted...

14 Mar 2019

Extra sleep on the weekend does not help

Extra sleep on the weekend does not help

If you are someone who believes in catching up on your lost sleep on the weekends, a recent study suggests that it doesn’t work that way. In fact, on some health measures, trying to play catch-up for a few days and then returning to poor sleep habits makes things worse. "Our findings suggest t...

02 Mar 2019

It’s chicken pox season

It’s chicken pox season

“Mom, look at this bubble on my belly,” said seven-year-old Snigdha rushing to her mother. “I feel itchy though,” she continued. That was enough to make alarm bells ring and a consultation with the family doctor confirmed the fears of chicken pox. The mandatory one-week rest ...

28 Feb 2019

Brain stimulation may relieve depression...

Brain stimulation may relieve depression symptoms:...

According to a study, analysing the stimulation of the brain functions might relieve depression symptoms in people. For the study, the researchers at the University of California recruited 25 patients, who reported minimal to severe symptoms of depression, and asked them to report their mood several...

01 Dec 2018

Study: High carb, low-protein diet may l...

Study: High carb, low-protein diet may lead to bet...

According to the news trend in health eating, it is noticed that low-carb and high-protein diets are ruling the roost, as they are considered healthy and perfect for weight loss. However, as per a particular study published in the Journal Cell Reports is stating something different. The team of rese...

27 Nov 2018

Health research body to conduct trials o...

Health research body to conduct trials on Zika vac...

The ICMR will be taking up the second phase of trials to assess the efficacy of the vaccine and determine its side effects. Earlier this year, a Zika virus was reported in parts of Rajasthan, Madhya Pradesh and Gujarat. Following this, the Indian Council of Medical Research (ICMR) will be conducting...

24 Nov 2018

Six surprising drug interactions you sho...

Six surprising drug interactions you should know a...

As the UK population grows older, more and more people are using a combination of drugs to treat multiple conditions. This can lead to interactions and side effects that we all need to be aware of. Not only can drugs interact with each other, they can also interact with food and drink, as well as po...

23 Nov 2018